Saccharin, aspartame and sucralose were supposed to help us lose weight. All sweetness and no calories. The chemicals may play tricks on our palates but not on our metabolisms. Weight gain and glucose intolerance may follow.
Read the excellent article on International Probiotics Association website about how microbes may be involved.
Explanations are many: Increased absorption, increased appetite and changes in insulin response. But researchers at Weizmann Institute of Science in Rehovot in Israel, suggest differences in the microbiome. They demonstrated how non-caloric artificial sweeteners may induce glucose intolerance in mice and certain humans by changing the gut microbiome.
Read more here.