The advent of high fructose corn syrup in our diets correlates with soaring obesity rates. Some but not all data point to insulin resistance caused by inflammatory factors in fat tissue.
A new study in Nutrition and Diabetes tested this theory. For 10 months, mice were fed either a regular diet, a high-fat diet or a regular diet with 8% HFCS (such as a diet with soft drinks).
Results? The HFCS chow caused more severe adipose inflammation and insulin resistance than the other two. When ghrelin (the hunger hormone) was removed from the mice, the inflammation decreased.
HFCS appears to affect metabolism in ways that can contribute to obesity.